The Matrix Health All medications
Non-GLP-1 weight-loss combination
Contrave
Bupropion Hydrochloride + Naltrexone Hydrochloride · Daily oral tablet
Oral combination therapy that targets appetite and reward pathways — a non-injectable option.
How it works
Combines naltrexone and bupropion to reduce cravings and food-related reward signals.
Who it's for
- Patients who cannot or prefer not to use GLP-1s
- Emotional / reward-driven eating
Common side effects
NauseaHeadacheInsomniaDry mouth
This is not a complete list. Your clinician will review your full medical history and discuss risks, contraindications, and monitoring before prescribing.
Not appropriate for patients with seizure disorders or uncontrolled hypertension.
Not sure which is right for you?
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